EED226 (Standard)

CAT: 0804-HY-101117RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-101117RSize:1 Each
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Description
EED226 (Standard) is the analytical standard of EED226 (HY-101117) . This product is intended for research and analytical applications. EED226 is a polycomb repressive complex 2 (PRC2) inhibitor, which binds to the K27me3-pocket on embryonic ectoderm development (EED) and shows strong antitumor activity in xenograft mice model[1]. EED226 is a potent, selective, and orally bioavailable EED inhibitor[2]. EED226 inhibits PRC2 with an IC50 of 23.4 nM when the H3K27me0 peptide is used as a substrate in the in vitro enzymatic assays[3].
CAS Number
[2083627-02-3]
Target
Histone Methyltransferase; Reference Standards
Related Pathways
Epigenetics; Others
Field of Research
Cancer
Smiles
O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
Molecular Formula
C17H15N5O3S
Molecular Weight
369.40
References & Citations
[1]Huang Y, et al. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem. 2017 Mar 23;60 (6) :2215-2226.|[2]Li L, et al. Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED. PLoS One. 2017 Jan 10;12 (1) :e0169855.|[3]Qi W, et al. An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED. Nat Chem Biol. 2017 Apr;13 (4) :381-388.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
MBS3607419-01EED226
A20673-50EED226 50mg
MF-0034933EED226-COOH
A20673-10EED226 10mg
A20673-2EED226 2mg
A20673-25EED226 25mg
A20673-5EED226 5mg
A20673-100EED226 100mg
A20673-10mM-DEED226 10mM * 1mL in DMSO
abx098967-01Standard

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