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Suvecaltamide (Standard)

CAT: 0804-HY-101096RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101096RSize:1 Each
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Description
Suvecaltamide (Standard) is the analytical standard of Suvecaltamide. This product is intended for research and analytical applications. Suvecaltamide (MK-8998) is a selective T-type calcium channel inhibitor with oral efficacy. Suvecaltamide exhibits no cytotoxicity in myeloma cell lines and does not affect the antitumor efficacy of Bortezomib (BTZ). Suvecaltamide reverses BTZ-induced peripheral neuropathy (CIPN) in mouse and rat models, and helps inhibit myeloma growth[1].
CAS Number
953778-58-0
Target
Calcium Channel; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cancer; Neurological Disease
Smiles
O=C(N[C@@H](C1=NC=C(OCC(F)(F)F)C=C1)C)CC2=CC=C(C(C)C)C=C2
Molecular Formula
C20H23F3N2O2
Molecular Weight
380.40
References & Citations
[1]Cristina Meregalli, et al. Reversal of Bortezomib-Induced Neurotoxicity by Suvecaltamide, a Selective T-Type Ca-Channel Modulator, in Preclinical Models. Cancers (Basel) . 2021 Oct 7;13 (19) :5013.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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