HA-100 (Standard)

• Description:

  HA-100 (Standard) is the analytical standard of HA-100 (HY-100984) . This product is intended for research and analytical applications. HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor[1][2].

• Target:

  Myosin; PKA; PKC; Reference Standards; ROCK

• Related Pathways:

  Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Others; Stem Cell/Wnt; TGF-beta/Smad

• Field of Research:

  Cancer

• Smiles:

  O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O

• Molecular Formula:

  C13H15N3O2S

• Molecular Weight:

  277.34

• References & Citations:

  [1]Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32 (1) :7-12.|[2]Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6 (3) :e17557.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [84468-24-6]