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Dilazep

CAT: 0804-HY-100957ASize: 1 EachDry Ice: NoHazardous: No
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Description
Dilazep is an inhibitor of adenosine uptake. Dilazep has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides[1][2].
CAS Number
35898-87-4
UNSPSC
12352005
Target
Nucleoside Transporters
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C(C1=CC(OC)=C(OC)C(OC)=C1)OCCCN2CCN(CCCOC(C3=CC(OC)=C(OC)C(OC)=C3)=O)CCC2
Molecular Formula
C31H44N2O10
Molecular Weight
604.69
References & Citations
[1]Zhang Y, et al. Dilazep potentiation of adenosine-mediated superior mesenteric arterial vasodilation. J Pharmacol Exp Ther. 1991 Sep;258 (3) :767-71.|[2]Kawagoe J, et al. Effect of dilazep dihydrochloride against ischemia and reperfusion-induced disruption of blood-brain barrier in rats: a quantitative study. Naunyn Schmiedebergs Arch Pharmacol. 1992 Apr;345 (4) :485-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Dilazep

Dilazep is a member of the class of diazepanes that is 1,4-diazepane substituted by 3-[(3,4,5-trimethoxybenzoyl)oxy]propyl groups at positions 1 and 4. It is a potent adenosine uptake inhibitor that exhibits antiplatelet, antianginal and vasodilator properties. It has a role as a vasodilator agent, a platelet aggregation inhibitor and a cardioprotective agent. It is a benzoate ester, a diazepane, a diester and a member of methoxybenzenes. It is a conjugate base of a dilazep(2+).

CAS Number35898-87-4
PubChem CID3074
IUPAC Name3-[4-[3-(3,4,5-trimethoxybenzoyl)oxypropyl]-1,4-diazepan-1-yl]propyl 3,4,5-trimethoxybenzoate
Molecular FormulaC31H44N2O10
Molecular Weight604.7
XLogP4.1
Topological Polar Surface Area114
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count12
Rotatable Bond Count18
Heavy Atom Count43
Formal Charge0
Complexity727
SMILES
COC1=CC(=CC(=C1OC)OC)C(=O)OCCCN2CCCN(CC2)CCCOC(=O)C3=CC(=C(C(=C3)OC)OC)OC
InChI
InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3
InChIKey
QVZCXCJXTMIDME-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Dilazep
CAS: 35898-87-4
CID: 3074
Formula: C31H44N2O10
MW: 604.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight604.7
XLogP34.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count12
Rotatable Bond Count18
Exact Mass604.29959560
Monoisotopic Mass604.29959560
Topological Polar Surface Area114 Ų
Heavy Atom Count43
Formal Charge0
Complexity727
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
RM-D092900-01Dilazep
255145Dilazep dihydrochloride
598179Dilazep HCl

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