Navitoclax (Standard)

CAT: 0804-HY-10087R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10087R-01Size:5 mg
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Description
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM[1].
CAS Number
[923564-51-6]
Product Name Alternative
ABT-263 (Standard)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bcl-2 Family; Reference Standards
Related Pathways
Apoptosis; Others
Field of Research
Cancer
Purity
99.14
Smiles
O=S(C1=CC(S(NC(C2=CC=C(N3CCN(CC4=C(CCC(C)(C4)C)C5=CC=C(Cl)C=C5)CC3)C=C2)=O)(=O)=O)=CC=C1N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)(C(F)(F)F)=O
Molecular Formula
C47H55ClF3N5O6S3
Molecular Weight
974.61
Precautions
H302, H315, H319, H335
References & Citations
[1]Lock R1, et al. Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008 Jun;50 (6) :1181-1189.|[2]Wong M, et al. Navitoclax (ABT-263) reduces Bcl-x (L) -mediated chemoresistance in ovarian cancer models.Mol Cancer Ther. 2012 Apr;11 (4) :1026-1035.|[3]Chen J, et al. The Bcl-2/Bcl-X (L) /Bcl-w inhibitor, navitoclax, enhances the activity of chemotherapeutic agents in vitro and in vivo. Mol Cancer Ther. 2011 Dec;10 (12) :2340-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards

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