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ON1231320 (Standard)

CAT: 0804-HY-100789RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100789RSize:1 Each
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Description
ON1231320 (Standard) is the analytical standard of ON1231320. This product is intended for research and analytical applications. ON1231320 is a highly specific polo like kinase 2 (PLK2) inhibitor with an IC50 of 0.31 μM. ON1231320 blocks tumor cell cycle progression in the G2/M phase in mitosis, causing apoptotic cell death. ON1231320, an arylsulfonyl pyrido-pyrimidinone, has antitumor activity[1][2].
CAS Number
1312471-39-8
Target
Apoptosis; Mitosis; Polo-like Kinase (PLK) ; Reference Standards
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
O=C1C(S(=O)(C2=CC=C(F)C=C2F)=O)=CC3=CN=C(NC4=CC5=C(NC=C5)C=C4)N=C3N1C
Molecular Formula
C22H15F2N5O3S
Molecular Weight
467.45
References & Citations
[1]M V Ramana Reddy, et al. Discovery of 2- (1H-indol-5-ylamino) -6- (2,4-difluorophenylsulfonyl) -8-methylpyrido[2,3-d]pyrimidin-7 (8H) -one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2) . Bioorg Med Chem. 2016 Feb 15;24 (4) :521-44.|[2]Shashidhar S. Jatiani, et al. Abstract 643: Targeting cancer with a selective ATP-mimetic inhibitor of polo like kinase-2.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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