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Dihydrokainic acid (Standard)

CAT: 0804-HY-100784RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100784RSize:1 Each
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Description
Dihydrokainic acid (Standard) is the analytical standard of Dihydrokainic acid. This product is intended for research and analytical applications. Dihydrokainic acid (DHK) is a glutamate transporter GLT1 (EAAT2) inhibitor. Dihydrokainic acid impairs novel object recognition (NOR) memory performance in mice. Dihydrokainic acid also shows epileptogenic effects[1].
CAS Number
52497-36-6
UNSPSC
12352005
Target
EAAT; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Neurological Disease
Smiles
O=C(O)C[C@@H]1[C@@H](C(O)=O)NC[C@@H]1C(C)C
Molecular Formula
C10H17NO4
Molecular Weight
215.25
References & Citations
[1]Lehmann A, et al. Dihydrokainic acid affects extracellular taurine and phosphoethanolamine levels in the hippocampus. Neuroscience Letters, 1983, 38 (1) : 67-72. |[2]Bouazzaoui M, et al. Kainic acid, AMPA, and dihydrokainic acid effect on uptake and efflux of D-[3H] aspartic acid in cerebellar slices. Neurochem Res. 1996 Dec;21 (12) :1527-33.|[3]Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27 (4) :375-81.|[4]Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32.|[5]Muñoz M D, et al. Effects of dihydrokainic acid of extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology, 1987, 26 (1) : 1-8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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