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Splitomicin (Standard)

CAT: 0804-HY-100585RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100585RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Splitomicin (Standard) is the analytical standard of Splitomicin. This product is intended for research and analytical applications. Splitomicin (Splitomycin) is a selective Sir2p inhibitor. Splitomicin inhibits NAD+-dependent HDAC activity of Sir2 protein. Splitomicin induces dose-dependent inhibition of HDAC in the yeast extract with an IC50 of 60 μM[1].
CAS Number
5690-03-9
Product Name Alternative
Splitomycin (Standard)
UNSPSC
12352005
Target
HDAC; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer
Smiles
O=C1CCC2=C3C=CC=CC3=CC=C2O1
Molecular Formula
C13H10O2
Molecular Weight
198.22
References & Citations
[1]Bedalov A, et al. Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A. 2001 Dec 18;98 (26) :15113-8.|[2]Breitenstein A, et al. Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells. Cardiovasc Res. 2011 Feb 1;89 (2) :464-72.|[3]Ota H, et al. Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells. Oncogene. 2006 Jan 12;25 (2) :176-85.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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