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BMY 7378 (Standard)

CAT: 0804-HY-100554RSize: 1 EachDry Ice: NoHazardous: No
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Description
BMY 7378 (Standard) is the analytical standard of BMY 7378. This product is intended for research and analytical applications. BMY 7378 is a selective antagonist of α1D-adrenoceptor (α1D-AR). BMY 7378 binds to membranes expressing the cloned rat α1D-AR with a >100-fold higher affinity (Ki=2 nM) than binding to either the cloned rat α1A-AR (Ki=800 nM) or the hamster α1B-AR (Ki=600 nM). BMY 7378 is a 5-HT1A receptor partial agonist[1][2].
CAS Number
21102-95-4
Target
5-HT Receptor; Adrenergic Receptor; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(N(CCN1CCN(C2=CC=CC=C2OC)CC1)C(C3)=O)CC43CCCC4.[H]Cl.[H]Cl
Molecular Formula
C22H33Cl2N3O3
Molecular Weight
458.42
References & Citations
[1]Piascik MT, et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther. 1995;275 (3) :1583-1589.|[2]Goetz AS, et al. BMY 7378 is a selective antagonist of the D subtype of alpha 1-adrenoceptors. Eur J Pharmacol. 1995;272 (2-3) :R5-R6.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Bmy-7378
CAS Number21102-95-4
PubChem CID210172
IUPAC Name8-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione;dihydrochloride
Molecular FormulaC22H33Cl2N3O3
Molecular Weight458.4
Topological Polar Surface Area53.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity547
SMILES
COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl
InChI
InChI=1S/C22H31N3O3.2ClH/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22;;/h2-3,6-7H,4-5,8-17H2,1H3;2*1H
InChIKey
NIBOMXUDFLRHRV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bmy-7378
CAS: 21102-95-4
CID: 210172
Formula: C22H33Cl2N3O3
MW: 458.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass457.1898973
Monoisotopic Mass457.1898973
Topological Polar Surface Area53.1 Ų
Heavy Atom Count30
Formal Charge0
Complexity547
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count3
Compound Is CanonicalizedYes

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B2263-50BMY 7378
WAA10295-01BMY 7378 Dihydrochloride
A11208-200BMY 7378 200mg
A11208-25BMY 7378 25mg
522666BMY-7378 HCl
A11208-10BMY 7378 10mg
A11208-50BMY 7378 50mg

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