NPS-1034 (Standard)

CAT: 0804-HY-100509RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100509RSize:1 Each
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Description
NPS-1034 (Standard) is the analytical standard of NPS-1034 (HY-100509) . This product is intended for research and analytical applications. NPS-1034 is a dual inhibitor of AXL and MET with IC50s of 10.3 and 48 nM, respectively.
CAS Number
[1221713-92-3]
Target
Apoptosis; c-Met/HGFR; Reference Standards; TAM Receptor
Related Pathways
Apoptosis; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(C1=C(C)N(C)N(C2=CC=C(F)C=C2)C1=O)NC3=CC=C(OC4=C5C(NC=C5C6=CC=CC=C6)=NC=C4)C(F)=C3
Molecular Formula
C31H23F2N5O3
Molecular Weight
551.54
References & Citations
[1]Rho JK, et al. MET and AXL inhibitor NPS-1034 exerts efficacy against lung cancer cells resistant to EGFR kinase inhibitors because of MET or AXL activation. Cancer Res. 2014 Jan 1;74 (1) :253-62.|[2]Shin JS, et al. NPS-1034, a novel MET inhibitor, inhibits the activated MET receptor and its constitutively active mutants. Invest New Drugs. 2014 Jun;32 (3) :389-99.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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