Avadomide (Standard)

• Description :

  Avadomide (Standard) is the analytical standard of Avadomide. This product is intended for research and analytical applications. Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities[1][2][3].

• Product Name Alternative :

  CC 122 (Standard)

• UNSPSC :

  12352005

• Target :

  Apoptosis; E1/E2/E3 Enzyme; Molecular Glues; NF-κB; Reference Standards

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease; NF-κB; Others; PROTAC

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O

• Molecular Formula :

  C14H14N4O3

• Molecular Weight :

  286.29

• References & Citations :

  [1]Hagner, P.R.et al.CC-122, a pleiotropic pathway modifier, mimics an IFN response and has antitumor activity in DLBCL.Blood.Aug 6;126 (6) :779-89.|[2]Rasco DW, et al. A First-in-Human Study of Novel Cereblon Modulator Avadomide (CC-122) in Advanced Malignancies. Clin Cancer Res. 2019 Jan 1;25 (1) :90-98.|[3]Nishi H, et al., Anti-tumor effect of avadomide in gemcitabine-resistant pancreatic ductal adenocarcinoma. Cancer Chemother Pharmacol. 2023 Oct;92 (4) :303-314.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [1015474-32-4]