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Hydronidone (Standard)

CAT: 0804-HY-100438RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100438RSize:1 Each
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Description
Hydronidone (Standard) is the analytical standard of Hydronidone. This product is intended for research and analytical applications. Hydronidone is an orally active pyridine derivative. Hydronidone is an inhibitor of phosphodiesterase-4 (PDE4) and cyclo-oxygenase (COX) as well as TGF-β. Hydronidone induces mitochondrial dysfunction and triggers apoptosis. Hydronidone can be used for liver fibrosis, anti-inflammation and anti-cancer study[1][2][3].
CAS Number
851518-71-3
Target
Apoptosis; COX; Mitochondrial Metabolism; Phosphodiesterase (PDE) ; Reference Standards; TGF-beta/Smad
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C=CC(C)=CN1C2=CC=C(O)C=C2
Molecular Formula
C12H11NO2
Molecular Weight
201.22
References & Citations
[1]Xu X, et al. Hydronidone ameliorates liver fibrosis by inhibiting activation of hepatic stellate cells via Smad7-mediated degradation of TGFβRI. Liver Int. 2023 Nov;43 (11) :2523-2537.|[2]Sun Z, et al. Hydronidone induces apoptosis in activated hepatic stellate cells through endoplasmic reticulum stress-associated mitochondrial apoptotic pathway. J Gastroenterol Hepatol. 2024 Aug;39 (8) :1695-1703.|[3]Juillerat-Jeanneret L, et al. Fibrogenic Disorders in Human Diseases: From Inflammation to Organ Dysfunction. J Med Chem. 2018 Nov 21;61 (22) :9811-9840.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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