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PACMA 31 (Standard)

CAT: 0804-HY-100433RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100433RSize:1 Each
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Description
PACMA 31 (Standard) is the analytical standard of PACMA 31. This product is intended for research and analytical applications. PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
1401089-31-3
Target
PDI; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
COC1=CC=C(N(C(C2=CC=CS2)C(NCC(OCC)=O)=O)C(C#C)=O)C(OC)=C1
Molecular Formula
C21H22N2O6S
Molecular Weight
430.47
References & Citations
[1]Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012;109 (40) :16348-16353.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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