PACMA 31 (Standard)

• Description:

  PACMA 31 (Standard) is the analytical standard of PACMA 31 (HY-100433) . This product is intended for research and analytical applications. PACMA 31 is an irreversible, orally active protein disulfide isomerase (PDI) inhibitor with an IC50 of 10 μM. PACMA 31 forms a covalent bond with the active site cysteines of PDI. PACMA 31 shows tumor targeting ability and significantly suppresses ovarian tumor growth without causing toxicity to normal tissues[1]. PACMA 31 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target:

  PDI; Reference Standards

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

• Field of Research:

  Cancer

• Smiles:

  COC1=CC=C (N (C (C2=CC=CS2) C (NCC (OCC) =O) =O) C (C#C) =O) C (OC) =C1

• Molecular Formula:

  C21H22N2O6S

• Molecular Weight:

  430.47

• References & Citations:

  [1]Xu S, et al. Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment. Proc Natl Acad Sci U S A. 2012;109 (40) :16348-16353.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  1401089-31-3