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LOC14 (Standard)

CAT: 0804-HY-100432RSize: 1 EachDry Ice: NoHazardous: No
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Description
LOC14 (Standard) is the analytical standard of LOC14. This product is intended for research and analytical applications. LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC50 and Kd values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding[1]. LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells[3].
CAS Number
877963-94-5
Target
PDI; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C(C=CC=C1)=C1S2)N2CN3CCN(C(C4CC4)=O)CC3
Molecular Formula
C16H19N3O2S
Molecular Weight
317.41
References & Citations
[1]Kaplan A, et al. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proc Natl Acad Sci U S A. 2015 Apr 28;112 (17) :E2245-52.|[2]Chamberlain N, et al. Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics. Redox Biol. 2019 Apr;22:101129.|[3]Zhou X, et al. Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease. Hum Mol Genet. 2018 May 1;27 (9) :1545-1555.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
BA4401-50LOC14
A20491-100LOC14 100mg
A20491-50LOC14 50mg
A20491-25LOC14 25mg
A20491-10LOC14 10mg
A20491-5LOC14 5mg
abx098967-01Standard

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