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PCI-33380 (Standard)

CAT: 0804-HY-100335RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-100335RSize:1 Each
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Description
PCI-33380 (Standard) is the analytical standard of PCI-33380. This product is intended for research and analytical applications. PCI-33380 is a fluorescent probe ((Ex=532 nm, Em=555 nm). PCI-33380 consists of a (BTK) inhibitor PCI-32765 (HY-10997) attaching with a Bodipy-FL fluorophore via a piperazine linker. PCI-33380 binds predominantly to Btk in B cell lysates with cell permeable activity. PCI-33380 can be used for imaging live cancer cells such as non-Hodgkin lymphoma research[1][2]
CAS Number
1022899-36-0
Target
Btk; Fluorescent Dye; Reference Standards
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
NC1=C(C(C2=CC=C(OC3=CC=CC=C3)C=C2)=NN4C(CCC5)CN5C(/C=C/CN6CCN(CCNC(CCC7=CC=C(C=C(C(C)=C8)[N]9=C8C)[N-]7[B+3]9([F-])[F-])=O)CC6)=O)C4=NC=N1
Molecular Formula
C46H52BF2N11O3
Molecular Weight
855.78
References & Citations
[1]Zuo Y, et al. A novel 2,5-diaminopyrimidine-based affinity probe for Bruton's tyrosine kinase. Sci Rep. 2015 Nov 4;5:16136.|[2]Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107 (29) :13075-80.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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