EAI045 (Standard)

• Description :

  EAI045 (Standard) is the analytical standard of EAI045 (HY-100213) . This product is intended for research and analytical applications. EAI045 is an allosteric and the fourth-generation inhibitor of mutant EGFR with IC50s of 1.9, 0.019, 0.19 and 0.002 μM for EGFR, EGFRL858R, EGFRT790M and EGFRL858R/T790M at 10 μM ATP, respectively.

• Target :

  EGFR; Reference Standards

• Related Pathways :

  JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Smiles :

  O=C(C(C1=C(O)C=CC(F)=C1)N2C(C(C=CC=C3)=C3C2)=O)NC4=NC=CS4

• Molecular Formula :

  C19H14FN3O3S

• Molecular Weight :

  383.40

• References & Citations :

  [1]Jia Y, et al. Overcoming EGFR (T790M) and EGFR (C797S) resistance with mutant-selective allosteric inhibitors. Nature. 2016 Jun 2;534 (7605) :129-32.|[2]Wang S, et al. EAI045: The fourth-generation EGFR inhibitor overcoming T790M and C797S resistance. Cancer Lett. 2017 Jan 28;385:51-54.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [1942114-09-1]