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AZD9362

CAT: 0804-HY-100038Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100038Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZD9362 is a reversible, ATP-competitive and orally active small molecule inhibitor of IGF-1R and insulin receptor. AZD9362 inhibits the IGF-1R enzyme with an IC50 of 14 nM. AZD9362 can enhance the anti-tumor effect of AZD5363 (HY-15431) . AZD9362 can be used for the research of cancer, such as breast cancer[1].
CAS Number
[1905412-80-7]
UNSPSC
12352005
Target
IGF-1R; Insulin Receptor
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=NN(C2CCN(C([C@H](O)C)=O)CC2)C(C)=C1NC3=NC=C(Cl)C(C4=C5C=CC=CN5N=C4)=N3
Molecular Formula
C24H27ClN8O2
Molecular Weight
494.98
References & Citations
[1]Fox EM, et al. Autocrine IGF-I/insulin receptor axis compensates for inhibition of AKT in ER-positive breast cancer cells with resistance to estrogen deprivation. Breast Cancer Res. 2013;15 (4) :R55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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