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NT157 (Standard)

CAT: 0804-HY-100037RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-100037RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NT157 (Standard) is the analytical standard of NT157 (HY-100037) . This product is intended for research and analytical applications. NT157 (Tyrphostin NT157) is a selective IRS-1/2 inhibitor that induces Ser-phosphorylation and consequently the degradation of IRS-1/2. NT157 (Tyrphostin NT157) is a first-in-class anti-cancer agent that also targets Stat3 signaling pathway[1][2].
CAS Number
[1384426-12-3]
Target
Insulin Receptor; Reference Standards; STAT
Related Pathways
JAK/STAT Signaling; Others; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer; Endocrinology
Smiles
S=C(NCC1=CC(O)=C(O)C(O)=C1)/C=C/C2=CC(O)=C(O)C(Br)=C2
Molecular Formula
C16H14BrNO5S
Molecular Weight
412.26
References & Citations
[1]Downregulated the Tyr-phosphorylation of IRS-1 in the MG-63 and U-2OS cells.|[2]Flashner-Abramson E, et al. Targeting melanoma with NT157 by blocking Stat3 and IGF1R signaling. Oncogene. 2016 May 19;35 (20) :2675-80.|[3]Ibuki N, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014 Dec;13 (12) :2827-39.|[4]Ishii H, et al. miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat Commun. 2018 Jul 4;9 (1) :2611.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
MBS3616917-01NT157
A16247-1NT157 1mg
A16247-50NT157 50mg
A16247-2NT157 2mg
A16247-5NT157 5mg
A16247-10NT157 10mg
A16247-25NT157 25mg
A16247-100NT157 100mg
A16247-10mM-DNT157 10mM * 1mL in DMSO
abx098967-01Standard

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