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BAY-876 (Standard)

CAT: 0804-HY-100017RSize: 1 EachDry Ice: NoHazardous: No
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Description
BAY-876 (Standard) is the analytical standard of BAY-876. This product is intended for research and analytical applications. BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3].
CAS Number
1799753-84-6
Target
Disulfidptosis; GLUT; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
O=C(C1=NC2=CC(F)=CC=C2C(C(NC3=C(C)N(CC4=CC=C(C#N)C=C4)N=C3C(F)(F)F)=O)=C1)N
Molecular Formula
C24H16F4N6O2
Molecular Weight
496.42
References & Citations
[1]Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23.|[2]Ma Y, et al. Ovarian Cancer Relies on Glucose Transporter 1 to Fuel Glycolysis and Growth: Anti-Tumor Activity of BAY-876. Cancers (Basel) . 2018 Dec 31;11 (1) .|[3]Zhang R, et al. Reductive cell death: the other side of the coin[J]. Cancer Gene Therapy, 2023, 30 (7) : 929-931.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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Alternative Products

CatalogName
BA6712-100BAY-876
6199/5BAY 876

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