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Plitidepsin

CAT: 0804-HY-16050-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16050-01Size:1 mg
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Description
Plitidepsin (Aplidine) is a potent anti-cancer agent by targeting eEF1A2 (KD=80 nM) [1]. Plitidepsin possesses antiviral activity and is against SARS-CoV-2 with an IC90 of 0.88 nM. Plitidepsin is usually used for multiple myeloma and advanced cancer research, and has the potential for COVID-19 research[1][2].
CAS Number
137219-37-5
Product Name Alternative
Aplidine; PM90001
UNSPSC
12352209
Hazard Statement
H225-H302+H312+H332-H319
Target
DNA/RNA Synthesis; SARS-CoV
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/plitidepsin.html
Purity
99.99
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](NC([C@H](C([C@@H](OC(C[C@@H]1O)=O)C(C)C)=O)C)=O)CC(C)C)N(CCC2)[C@]2([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]1([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H](CCC3)N3C(C(C)=O)=O)=O)=O)C)=O)CC(C=C4)=CC=C4OC)C)=O
Molecular Formula
C57H87N7O15
Molecular Weight
1110.34
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P362+P364-P370+P378-P403+P235-P501
References & Citations
[1]Alejandro Losada, et al. Translation Elongation Factor eEF1A2 is a Novel Anticancer Target for the Marine Natural Product Plitidepsin. Sci Rep. 2016 Oct 7;6:35100.|[2]Kris M White, et al. Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A. Science. 2021 Feb 26;371 (6532) :926-931.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Natural Products
Clinical Information
Launched

Alternative Products

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200150Plitidepsin
A22480-10Plitidepsin 10mg
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A22480-100Plitidepsin 100mg
A22480-50Plitidepsin 50mg
A22480-25Plitidepsin 25mg
AR-P32036-01Plitidepsin (Aplidine)
A22480-10mM-DPlitidepsin 10mM * 1mL in DMSO

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