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Givastomig

CAT: 0804-HY-P990742-01Size: 1 mgDry Ice: YesHazardous: No
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CAT#:0804-HY-P990742-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Givastomig (ABL111, TJ033721) is a bispecific antibody (BsAb) inhibitor. Givastomig can specifically binds to Claudin18.2 (CLDN 18.2) on the surface of cancer cells and 4-1BB (CD137, TNFRSF9) on the surface of activated T cells and natural killer (NK) cells. Givastomig is engineered to contain a single Fc-domain mutation (asparagine to alanine) to eliminate Fc-effector function. Givastomig-bound cell lines expressing a range of CLDN18.2 levels with high affinity and induced 4-1BB activation only in the context of CLDN18.2 binding. Givastomig can be used for the study of colon carcinoma[1].
CAS Number
2762499-30-7
Product Name Alternative
TJ-CD4B; ABL111; TJ033721
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
Claudin; TNF Receptor
Type
Inhibitory Antibodies
Related Pathways
Apoptosis; Cytoskeleton
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/givastomig.html
Purity
98.556
Molecular Weight
(201.929 kDa)
Precautions
H302, H315, H319, H335
References & Citations
[1]Ku G, et al. A First-in-Human Study of Givastomig, a CLDN18.2 and 4-1BB Bispecific Antibody, as Monotherapy in Patients with CLDN18.2-Positive Advanced or Metastatic Solid Tumors. Clin Cancer Res. 2025 Jun 30:10.1158/1078-0432.CCR-24-4280. |[2]Gao J, et al. CLDN18.2 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN18.2-expressing tumor-directed T-cell activation. J Immunother Cancer. 2023 Jun;11 (6) :e006704.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Inhibitory Antibodies
Clinical Information
No Development Reported

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