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Rabbit Polyclonal Antibody to CUL5

CAT: 1725-P07227-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:1725-P07227-01Size:50 µL
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Description
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS (SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Product Name Alternative
VACM1, VACM-1
Swiss Prot
Q93034
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human CUL5
Clonality
Polyclonal
Applications
IHC
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Formulation
Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.
Antibody Type
Primary antibody
Protein Name
CUL5

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