Rabbit Polyclonal Antibody to PRKCH

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta) -activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA) . It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction.

PKCL; PKC-L; PRKCL; nPKC-eta

P24723

Human, Mouse, Rat

Synthetic peptide of human PRKCH

WB

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

Primary antibody

PRKCH