Orcinol

• Description:

  Orcinol (3,5-Dihydroxytoluene) is an organic compound used in biological dyeing and proteomics research. Orcinol inhibits melanogenesis in B16F10 cells by upregulating the MAPK/ERK signaling pathway, and suppresses the expression of MITF, tyrosinase (TYR), TRP1, and DCT. Orcinol exhibits certain DPPH radical scavenging activity. In addition, Orcinol can alter nitrogen balance in animals. Orcinol holds promise for research in cancer and metabolic diseases[1][2][3].

• Product Name Alternative:

  3,5-Dihydroxytoluene

• UNSPSC:

  12171500

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  ERK; Fluorescent Dye; p38 MAPK; Tyrosinase

• Type:

  Dye Reagents

• Related Pathways:

  MAPK/ERK Pathway; Metabolic Enzyme/Protease; Others; Stem Cell/Wnt

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/orcinol.html

• Purity:

  99.97

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  OC1=CC(C)=CC(O)=C1

• Molecular Formula:

  C7H8O2

• Molecular Weight:

  124.14

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Murakami Y, et al. The Radical Scavenging Activity and Cytotoxicity of Resveratrol, Orcinol and 4-Allylphenol and their Inhibitory Effects on Cox-2 Gene Expression and Nf-κb Activation in RAW264.7 Cells Stimulated with Porphyromonas gingivalis-fimbriae. In Vivo. 2015 May-Jun;29 (3) :341-9.|[2]Yu C L, et al. Orcinol inhibits melanogenesis in B16F10 cells via the upregulation of the MAPK/ERK signaling pathway[J]. Natural Product Communications, 2023, 18 (3) : 1934578X231156704.|[3]Edwards MJ, et al. Acid loads induced by the detoxification of plant secondary metabolites do not limit feeding by common brushtail possums (Trichosurus vulpecula) . J Comp Physiol B. 2010 Feb;180 (2) :247-57.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• Isoform:

  COX-2

• CAS Number:

  [504-15-4]