Products for Research Use Only
RegisterLogin

PX20606

CAT: 0804-HY-100443Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-100443Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PX20606 is an orally active agonist for farnesoid X receptor (FXR), with EC50 220 nM (mFXR) and 50 nM (hFXR), measured by Gal4-FXR assay. PX20606 induces the expression of tumor suppressor gene NDRG2, inhibits the tumor growth and metastasis in mouse HCC model. PX20606 exhibits hepatoprotective efficacy[1].
CAS Number
1268245-19-7
Product Name Alternative
PX-102
UNSPSC
12352005
Target
FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/px20606.html
Smiles
O=C(O)C(C=C1)=CC=C1C(C2)C2C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3Cl
Molecular Formula
C29H22Cl3NO4
Molecular Weight
554.85
References & Citations
[1]Deuschle U, et al., FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model. PLoS One. 2012;7 (10) :e43044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

Alternative Products

CatalogName
T88353-01PX20606
T12583-01PX20606 trans racemate
T12583L-01(-)-PX20606 trans isomer
MBS3841972-01PX20606 trans-isomer
TAC24488-01(-) -PX20606 trans isomer
A16997-10PX20606 trans-isomer 10mg
A16997-2PX20606 trans-isomer 2mg
A16997-25PX20606 trans-isomer 25mg
A16997-5PX20606 trans-isomer 5mg
A16997-100PX20606 trans-isomer 100mg

Popular Products