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Adamantanine

CAT: 0804-HY-121123-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121123-01Size:50 mg
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Description
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (Ki is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC50 of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S0.5 of 10.5[1].
CAS Number
42381-05-5
Product Name Alternative
2-Aminoadamantane-2-carboxylic acid
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Aminopeptidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/adamantanine.html
Purity
97.0
Solubility
10 mM in DMSO
Smiles
OC(C1([C@H]2C[C@H](C3)C[C@@H]1C[C@H]3C2)N)=O
Molecular Formula
C11H17NO2
Molecular Weight
195.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Nagasawa HT, et al., Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. J Med Chem. 1975 Aug;18 (8) :826-30.|[2]Nagaswa HT, et al., 2-Aminoadamantane-2-carboxylic acid, a rigid, achiral, tricyclic alpha-amino acid with transport inhibitory properties. J Med Chem. 1973 Jul;16 (7) :823-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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