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PD146176

CAT: 0804-HY-103157-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103157-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD146176 (NSC168807), a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM) . PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice[1][2][3].
CAS Number
4079-26-9
Product Name Alternative
NSC168807
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis; Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pd146176.html
Purity
99.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C1(N2)=C(CSC3=CC=CC=C31)C4=C2C=CC=C4
Molecular Formula
C15H11NS
Molecular Weight
237.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Sendobry SM, et al. Attenuation of diet-induced atherosclerosis in rabbits with a highly selective 15-lipoxygenase inhibitor lacking significant antioxidant properties. Br J Pharmacol. 1997;120 (7) :1199-1206.|[2]Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139 (1) :201]. Atherosclerosis. 1998;136 (2) :203-216.|[3]Di Meco A, et al. 12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice. Biol Psychiatry. 2017;81 (2) :92-100.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

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M24370-01PD146176
MBS387761-01PD146176 (NSC168807)
A13347-50PD146176 (NSC168807) 50mg
A13347-5PD146176 (NSC168807) 5mg
A13347-100PD146176 (NSC168807) 100mg
A13347-25PD146176 (NSC168807) 25mg
A13347-10PD146176 (NSC168807) 10mg
A13347-10mM-DPD146176 (NSC168807) 10mM * 1mL in DMSO

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