Tebipenem

• Description:

  Tebipenem is an orally available carbapenem antibiotic, shows broad-spectrum activity against Gram-positive and -negative bacteria, except for Pseudomonas aeruginosa.

• Product Name Alternative:

  LJC 11036

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Antibiotic; Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/Tebipenem.html

• Purity:

  99.69

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic) |H2O : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C (C (N1C2=O) =C (SC3CN (C4=NCCS4) C3) [C@H] (C) [C@]1 ([H]) [C@@]2 ([H]) [C@H] (O) C) O

• Molecular Formula:

  C16H21N3O4S2

• Molecular Weight:

  383.49

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Hazra S, et al. Tebipenem, a new carbapenem antibiotic, is a slow substrate that inhibits the β-lactamase from Mycobacterium tuberculosis. Biochemistry. 2014 Jun 10;53 (22) :3671-8|[2]Seenama C, et al. In vitro activity of tebipenem against Burkholderia pseudomallei. Int J Antimicrob Agents. 2013 Oct;42 (4) :375.|[3]Li H, et al. In vitro antibacterial activities of two novel oral antibiotics, tebipenem and cefditoren, and other comparators against community-acquired respiratory tract infection-associated bacterial pathogens: A multicentre study in China. Int J Antimicrob Agents. 2014 Jan;43 (1) :92-3.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 3

• Isoform:

  β-lactam

• CAS Number:

  161715-21-5