Obtusifolin

• Description:

  Obtusifolin, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway[1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein[2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  NF-κB

• Type:

  Natural Products

• Related Pathways:

  NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/obtusifolin.html

• Purity:

  99.91

• Solubility:

  DMSO : 10 mg/mL (ultrasonic)

• Smiles:

  O=C1C2=C(C=CC=C2O)C(C3=CC(C)=C(O)C(OC)=C13)=O

• Molecular Formula:

  C16H12O5

• Molecular Weight:

  284.26

• Precautions:

  H302

• References & Citations:

  [1]Choi BS, et al. Obtusifolin isolated from the seeds of Cassia obtusifolia regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via affecting NF-κB pathway. Phytother Res. 2019 Apr;33 (4) :919-928.|[2]Hsu YL, et al. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein. J Agric Food Chem. 2014 Dec 10;62 (49) :11933-40.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  NF-κB

• CAS Number:

  [477-85-0]