Sucralfate

• UNSPSC Description:

  Sucralfate (Sucrose octasulfate-aluminum complex) is a potent and orally active gastroprotectant with no systemic effects. Sucralfate inhibits peptic activity and binds to negatively charged subepithelial proteins exposed during mucosal injury, forming a viscous layer that protects the vascular bed and proliferative zone. Sucralfate is used for prevention and research of several gastrointestinal diseases in vivo[1][2].

• Target Antigen:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Inflammation/Immunology; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Sucralfate.html

• Solubility:

  1M NaOH : 20 mg/mL (ultrasonic;adjust pH to 12 with 1M NaOH)|DMSO : < 1 mg/mL|H2O : < 0.1 mg/mL

• Smiles:

  [OSO3[Al2(OH5)]][C@H]([C@@H](C[OSO3[Al2(OH5)]])O1)[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@]1(C[OSO3[Al2(OH5)]])O[C@@H]2[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@H](O[S]=O=O=O=[OH5]#[Al]#[Al])[C@@H](C[OSO3[Al2(OH5)]])O2

• Molecular Weight:

  2046.42

• References & Citations:

  [1]Chaim FM, et al. Evaluation of the application of enemas containing sucralfate in tissue content of neutral and acid mucins in experimental model of diversion colitis. Acta Cir Bras. 2014 Sep;29(9):544-52.|[2]Tracy L Hill, et al. Effect of sucralfate on gastric permeability in an ex vivo model of stress-related mucosal disease in dogs. J Vet Intern Med. 2018 Mar;32(2):670-678.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  54182-58-0