Topiroxostat

CAT: 0804-HY-14874-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-14874-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%) . Topiroxostat has the potential for hyperuricemia treatment[1][2].

CAS Number

577778-58-6

Product Name Alternative

FYX-051

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cytochrome P450; Xanthine Oxidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Topiroxostat.html

Concentration

10mM

Purity

99.95

Solubility

DMSO : 23.5 mg/mL (ultrasonic; warming)

Smiles

N#CC1=NC=CC(C2=NNC(C3=CC=NC=C3)=N2)=C1

Molecular Formula

C13H8N6

Molecular Weight

248.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Sato T, et al. Discovery of 3- (2-cyano-4-pyridyl) -5- (4-pyridyl) -1,2,4-triazole, FYX-051 - a xanthine oxidoreductase inhibitor for the treatment of hyperuricemia [corrected]. Bioorg Med Chem Lett. 2009 Nov 1;19 (21) :6225-9.|[2]Matsumoto K, et al. FYX-051: a novel and potent hybrid-type inhibitor of xanthine oxidoreductase. J Pharmacol Exp Ther. 2011 Jan;336 (1) :95-103.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

CYP3

Alternative Products

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B1192-10	Topiroxostat
TMIJ-0129-01	Topiroxostat-d4
RM-T161801-01	Topiroxostat Impurity A
CS-T-94273	Topiroxostat ACID
CS-T-94274	Topiroxostat Amide impurity
CS-P-02207	Topiroxostat Impurity 5

Topiroxostat

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