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(R) -KMH-233

CAT: 0931-TYD-02664-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TYD-02664-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2994330-89-9
Target
ASCT
Related Pathways
Membrane transporter/Ion channel
Bioactivity
(R) -KMH-233 is an isomer of KMH-233, which can serve as a reference compound in experiments. KMH-233 functions as a potent, reversible, and selective inhibitor of L-type amino acid transporter 1 (LAT1), effectively hindering the uptake of LAT1 substrate, l-leucine (IC50=18 μM), and also inhibiting cell growth. Even at a low concentration of 25 μM, KMH-233 significantly enhances the efficacy of Bestatin and cisplatin.
Smiles
N(C(=O)C1=CC(C[C@H](C(O)=O)N)=CC=C1)C=2N3C(C(C#N)=C(C2C#N)C4=CC=C(OCC(NC)=O)C=C4)=NC=5C3=CC=CC5
Molecular Formula
C32H25N7O5
Molecular Weight
587.58
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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RCD17413-01KMH-233
HY-120139A-01(R) -KMH-233
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