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MC-val-ala-nhs ester

CAT: 0931-TYD-02069-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TYD-02069-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1895916-22-9
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
MC-Val-Ala-NHS ester is a cleavable ADC linker featuring maleimide and NHS ester groups. The Val-Ala linker is susceptible to cleavage by cathepsin B. The maleimide group can react with thiol groups, as can the MC component. The NHS ester reacts specifically and efficiently with amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or mildly alkaline conditions, forming covalent bonds. Reagent grade, intended for research use only.
Smiles
O(C([C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@@H](C)C)=O)C)=O)N2C(=O)CCC2=O
Molecular Formula
C22H30N4O8
Molecular Weight
478.496
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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