HL2-m5

CAT: 0931-MF-0126803-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0126803-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2130846-15-8
Target
Hedgehog/Smoothened
Related Pathways
GPCR/G Protein|||Stem Cells
Bioactivity
HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.
Smiles
C([C@@H](C(N[C@H]1CC=2C=CC(=CC2)OCCSC[C@@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(N)=O)=O)[C@@H](C)O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC1=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(C)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)C=3C=4C(NC3)=CC=CC4
Molecular Formula
C70H101N15O24S3
Molecular Weight
1632.83
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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