QPH-FR

• Target :

  Wnt/beta-catenin

• Related Pathways :

  Stem Cells|||Cytoskeletal Signaling

• Bioactivity :

  QPH-FR is a quinoa peptide and acts as an inhibitor of the G protein-coupled receptor 5 (LGR5) that is abundant in leucine repeat sequences. By binding to LGR5, QPH-FR competitively inhibits the formation of the LGR5/RSPO1 complex. This interaction leads to the ubiquitination of FZD receptors by RNF43/ZNRF3, thereby inhibiting the Wnt/?-catenin signaling pathway and exerting stem cell suppression.

• Smiles :

  CC[C@H](C)[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CC=CC=C4)N

• Molecular Formula :

  C81H124N26O25

• Molecular Weight :

  1862.01

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C