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Tkip

CAT: 0931-TP2958-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TP2958-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
716361-65-8
Target
JAK, MHC
Related Pathways
Chromatin/Epigenetic, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Angiogenesis, Stem Cells, Immunology/Inflammation
Bioactivity
Tkip is a specific inhibitor of JAK2. It binds to the autophosphorylation site of JAK2, thereby inhibiting JAK2 autophosphorylation and the phosphorylation of the IFN-γ receptor subunit IFNGR-1. Tkip can suppress the antiviral activity of IFN-γ and the expression of MHC class I molecules. Tkip is applicable in studies related to the IFN-γ signaling pathway.
Smiles
C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@@H](CC5=CC=CC=C5)C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(=N)N)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC)C)=O)C(C)C)=O)=O)=O)[C@H](C)C)=O)CC(C)C)=O)N)C=7C=8C(NC7)=CC=CC8
Molecular Formula
C93H118N16O14
Molecular Weight
1684.03
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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