Braftide

CAT: 0931-TP2695-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TP2695-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2411851-64-2

Target

Raf, Ras, Kras

Related Pathways

MAPK

Bioactivity

Braftide is an allosteric inhibitor of BRAF kinase that exerts its effect by targeting the surface of BRAF kinase dimers, thereby preventing their formation. It inhibits both wild-type BRAF and oncogenic BRAFG469A, with IC50 values of 364 nM and 172 nM, respectively. When combined with the TAT sequence, Braftide can suppress the MAPK signaling pathway, inhibiting the proliferation of KRAS-mutant tumor cells, with EC50 values of 7.1 μM for HCT116 and 6.6 μM for HCT-15.

Smiles

[C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCSC)C(O)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(N)=O)=O)[C@H](C)C)=O

Molecular Formula

C57H94N16O13S

Molecular Weight

1243.52

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
CRB1001646-01	Braftide
GTR19144459-01	Tat-braftide
CRB1001646-01	Braftide - (Cancer Peptides)

Braftide

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