Nesiritide acetate

• Target:

  Others|||Natriuretic peptide|||Calcium Channel

• Related Pathways:

  Membrane transporter/Ion channel|||Others|||GPCR/G Protein|||Metabolism

• Bioactivity:

  Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.

• Smiles:

  C (C) (O) =O.C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (NCC (N[C@H] (C (NCC (N[C@@H]1C (=O) N[C@@H] (CC2=CC=CC=C2) C (=O) NCC (=O) N[C@@H] (CCCNC (=N) N) C (=O) N[C@@H] (CCCCN) C (=O) N[C@@H] (CCSC) C (=O) N[C@@H] (CC (O) =O) C (=O) N[C@@H] (CCCNC (=N) N) C (=O) N[C@@] ([C@H] (CC) C) (C (=O) N[C@@H] (CO) C (=O) N[C@@H] (CO) C (=O) N[C@@H] (CO) C (=O) N[C@@H] (CO) C (=O) NCC (=O) N[C@@H] (CC (C) C) C (=O) NCC (=O) N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@@H] (CC3=CN=CN3) C (O) =O) =O) CCCNC (=N) N) =O) CCCNC (=N) N) =O) CC (C) C) =O) [C@@H] (C) C) =O) CCCCN) =O) CSSC1) [H]) =O) =O) CO) =O) =O) CCC (N) =O) =O) [C@H] (C) C) =O) CCSC) =O) CCCCN) (=O) [C@H]4N (C ([C@H] (CO) N) =O) CCC4

• Molecular Formula:

  C143H244N50O42S4?C2H4O2

• Molecular Weight:

  3524.1

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1684439-46-0