Nesiritide acetate

• Target:

  Others|||Natriuretic peptide|||Calcium Channel

• Related Pathways:

  Membrane transporter/Ion channel|||Others|||GPCR/G Protein|||Metabolism

• Bioactivity:

  Nesiritide, a 32-amino acid natriuretic peptide and recombinant form of human brain natriuretic peptide, enhances vasorelaxation ex vivo in porcine hearts from an acute coronary occlusion model when given as a 2 µg/kg bolus dose followed by a 0.01 µg/kg per minute infusion, facilitated by the calcium ionophore A23187. Formulations containing nesiritide have been utilized in managing congestive heart failure.

• Smiles:

  C(C)(O)=O.C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)[C@@H](C)C)=O)CCCCN)=O)CSSC1)[H])=O)=O)CO)=O)=O)CCC(N)=O)=O)[C@H](C)C)=O)CCSC)=O)CCCCN)(=O)[C@H]4N(C([C@H](CO)N)=O)CCC4

• Molecular Formula:

  C143H244N50O42S4?C2H4O2

• Molecular Weight:

  3524.1

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1684439-46-0