Cholesterol sulfate

• Target :

  Glucocorticoid Receptor|||Serine Protease|||ROR

• Related Pathways :

  Endocrinology/Hormones|||Metabolism|||Proteases/Proteasome

• Purity :

  0.97

• Bioactivity :

  Cholesterol sulfate is a multifunctional endogenous sterol sulfate and selective DOCK2 inhibitor with an IC50 of 2 ?M in mouse assays. Cholesterol sulfate plays multiple roles including in epidermal barrier formation by regulating keratinocyte differentiation and corneocyte desquamation, functions as a serine-protease inhibitor, acts as a glucocorticoid receptor antagonist, and activates ROR?/? in the thymus. Cholesterol sulfate serves as a critical research tool for investigating cutaneous biology, immunomodulation, steroid metabolism, sperm capacitation, platelet aggregation, and disorders such as X-linked ichthyosis.

• Smiles :

  C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CCCC(C)C)C)(CC4)[H])[H])(CC=C1C[C@@H](OS(=O)(=O)O)CC2)[H])[H]

• Molecular Formula :

  C27H46O4S

• Molecular Weight :

  466.72

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1256-86-6