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Melicopine

CAT: 0931-TN8420-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN8420-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
568-01-4
Target
Parasite
Related Pathways
Microbiology/Virology
Bioactivity
Melicopine is an alkaloid found in Z. simulans, known for its antimalarial and anticancer properties. It inhibits P. falciparum strains, including chloroquine-sensitive 3D7 (IC50 of 29.7 μg/mL) and chloroquine-resistant Dd2 (IC50 of 33.7 μg/mL) . Additionally, Melicopine exhibits cytotoxicity against prostate cancer cells PC-3M (IC50 of 47.9 μg/mL) and LNCaP (IC50 of 37.8 μg/mL), but it is inactive in non-cancerous HEK293 cells (IC50 greater than 100 μg/mL) . Melicopine holds potential for research in anticancer and anti-infective applications.
Smiles
O=C1C=2C=CC=CC2N(C3=C4OCOC4=C(OC)C(OC)=C13)C
Molecular Formula
C17H15NO5
Molecular Weight
313.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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