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12-Deoxyphorbol 13-palmitate

CAT: 0931-TN8147-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN8147-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
66583-59-3
Target
Apoptosis, CDK
Related Pathways
Cell Cycle/Checkpoint, Apoptosis
Bioactivity
12-Deoxyphorbol 13-palmitate, a monomer derived from the roots of Euphorbia fischeriana, exhibits notable antitumor activity. This compound induces cell cycle arrest and apoptosis in gastric cancer cells by modulating key cell cycle regulators, such as cyclin B, cyclin A, and CDC2. Additionally, 12-Deoxyphorbol 13-palmitate significantly diminishes liver fibrosis by targeting APOL2 and impairing the APOL2–SERCA2–PERK–HES1 signaling pathway.
Smiles
O(C(CCCCCCCCCCCCCCC)=O)[C@@]12[C@@](C1(C)C)([C@]3([C@](O)([C@H](C)C2)[C@]4([C@](O)(CC(CO)=C3)C(=O)C(C)=C4)[H])[H])[H]
Molecular Formula
C36H58O6
Molecular Weight
586.84
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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