MAP3K5-IN-1

CAT: 0931-TN7602-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-TN7602-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2226941-29-1

Target

PKC, ROCK, p38 MAPK

Related Pathways

Cell Cycle/Checkpoint, Stem Cells, MAPK, Chromatin/Epigenetic, Cytoskeletal Signaling

Bioactivity

Compound 7, also known as 3′-O-Demethyl-4′-N-demethyl-4′-N-acetyl-4′-epi-staurosporine, serves as an inhibitor of protein kinases, displaying IC50 values of 0.092 μM for PKC-α, 0.26 μM for ROCK, and 0.77 μM for ASK1. Additionally, this compound exhibits significant cytotoxicity towards PC-3 cancer cells, with an IC50 of 0.16 μM [1].

Smiles

C[C@]12N3C=4C5=C(C6=C(C4C=7C3=CC=CC7)CNC6=O)C=8C(N5[C@](O1)(C[C@H](NC(C)=O)[C@H]2O)[H])=CC=CC8

Molecular Formula

C28H24N4O4

Molecular Weight

480.51

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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