Thujopsene

• Target :

  Others|||Antifungal|||Apoptosis|||Cytochromes P450|||PKM

• Related Pathways :

  Others|||Microbiology/Virology|||Metabolism|||Apoptosis

• Bioactivity :

  Thujopsene, a sesquiterpene found in T. dolabrata, exhibits a wide range of biological activities. It inhibits Na+/K+-ATPase and cytochrome P450 (CYP) isoform CYP2B6 with IC50 values of 25.9 µg/ml and Ki of 0.8 µM, respectively. Additionally, thujopsene demonstrates antimicrobial efficacy against both Gram-positive and Gram-negative bacteria, such as S. aureus, M. luteus, and S. typhimurium, with MICs ranging from 25-50 µg/ml. It also suppresses antigen-induced ?-hexosaminidase release in IgE-sensitized RBL-2H3 mast cells (IC50= 25.1 µM) and shows cytotoxicity against A549 non-small cell lung cancer cells with an LC50 of 35.27 µg/ml. Furthermore, thujopsene causes mortality in mites D. farinae and T. putrescentiae, with LC50s of 9.82 and 10.92 µg/cm2, respectively.

• Smiles :

  C[C@@]12[C@@]3([C@@](C3)(C(C)=CC1)[H])C(C)(C)CCC2

• Molecular Formula :

  C15H24

• Molecular Weight :

  204.35

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  470-40-6