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Lentztrehalose A

CAT: 0931-TN7283-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TN7283-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1609356-99-1
Target
Others, Endogenous Metabolite
Related Pathways
Metabolism, Others
Bioactivity
Lentztrehalose A, a disaccharide microbial metabolite identified in Lentzea, exhibits a range of biological activities. This compound specifically inhibits M. smegmatis trehalase—an enzyme involved in trehalose metabolism—more effectively than trehalase from porcine kidney, with IC50 values of 0.67 mM and >20 mM, respectively. Additionally, Lentztrehalose A at a concentration of 100 mM promotes autophagy in MeWo melanoma and OVK18 ovarian cancer cells. When administered at 50 mg/kg daily, it enhances survival rates and impedes tumor growth in a Sarcoma 180 murine sarcoma model.
Smiles
O([C@H]1O[C@H](CO)[C@@H](OC[C@@H](C(C)(C)O)O)[C@H](O)[C@H]1O)[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O
Molecular Formula
C17H32O13
Molecular Weight
444.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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HY-158793Lentztrehalose A
HY-156126Lentztrehalose C
GTR19233077-01Lentztrehalose B

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