Products for Research Use Only
RegisterLogin

Thienodolin

CAT: 0931-TN11084-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-TN11084-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
149127-27-5
Target
Others, STAT, NF-κB
Related Pathways
NF-κB, Others, JAK/STAT signaling, Stem Cells
Bioactivity
Thienodolin, an alkaloid discovered in S. albogriseolus, enhances root and shoot growth in rice seedlings at a concentration of 4 μM, but at 40 μM, it inhibits growth. It suppresses LPS-induced nitric oxide (NO) production with an IC50 of 17.2 μM, diminishes LPS-induced rises in inducible NO synthase (iNOS) levels, and hinders LPS-induced IκB degradation in RAW 264.7 macrophages.
Smiles
O=C(N)C=1SC=2NC=3C=C(Cl)C=CC3C2C1
Molecular Formula
C11H7ClN2OS
Molecular Weight
250.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

6-Chloro-8H-thieno(2,3-b)indole-2-carboxamide

Thienodolin is an indole alkaloid that is a thienoindole ring with carboxamide group and chlorine substituents at positions 2 and 6 respectively. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is an organic heterotricyclic compound, a monocarboxylic acid amide, an organochlorine compound, an organosulfur heterocyclic compound, an indole alkaloid and an aromatic amide.

CAS Number149127-27-5
PubChem CID442119
IUPAC Name6-chloro-4H-thieno[2,3-b]indole-2-carboxamide
Molecular FormulaC11H7ClN2OS
Molecular Weight250.70
XLogP3.2
Topological Polar Surface Area87.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity314
SMILES
C1=CC2=C(C=C1Cl)NC3=C2C=C(S3)C(=O)N
InChI
InChI=1S/C11H7ClN2OS/c12-5-1-2-6-7-4-9(10(13)15)16-11(7)14-8(6)3-5/h1-4,14H,(H2,13,15)
InChIKey
LREDECYEGMWOAR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-Chloro-8H-thieno(2,3-b)indole-2-carboxamide
CAS: 149127-27-5
CID: 442119
Formula: C11H7ClN2OS
MW: 250.70
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight250.70
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass249.9967617
Monoisotopic Mass249.9967617
Topological Polar Surface Area87.1 Ų
Heavy Atom Count16
Formal Charge0
Complexity314
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19255256-01Thienodolin

Popular Products