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TRAF3 Protein, Human, Recombinant

CAT: 0931-TMPH-02208-01Size: 5 µgDry Ice: NoHazardous: No
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CAT#:0931-TMPH-02208-01Size:5 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
Regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C