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Acalabrutinib-d4

CAT: 0931-TMIH-0065-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-TMIH-0065-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Bioactivity
Acalabrutinib-d4 is a deuterated compound of Acalabrutinib. Acalabrutinib has a CAS number of 1420477-60-6. Acalabrutinib, also known as ACP-196, is an orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, ACP-196 inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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