Apatinib-d8

• Target:

  Autophagy|||c-RET|||VEGFR|||c-Kit|||Src

• Related Pathways:

  Apoptosis|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Autophagy

• Bioactivity:

  Apatinib-d8 is a deuterated compound of Apatinib. Apatinib has a CAS number of 811803-05-1. Apatinib is an orally bioavailable and specific VEGFR2 inhibitor (IC50: 1 nM) . In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.

• Smiles:

  C(#N)C1(C(C(C(C1([2H])[2H])([2H])[2H])([2H])[2H])([2H])[2H])C2=CC=C(NC(=O)C3=C(NCC=4C=CN=CC4)N=CC=C3)C=C2

• Molecular Formula:

  C24H15D8N5O

• Molecular Weight:

  405.52

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2468771-43-7