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Carmofur

CAT: 0804-HY-B0182-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
CAT#:0804-HY-B0182-01Size:10 mM - 1 mL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carmofur (HCFU) is a rat recombinant acid ceramidase inhibitor with an IC50 of 29 nM. Carmofur is also a protease inhibitor of SARS-CoV-2 main protease (Mpro), fatty acid amide hydrolase (FAAH) and N-acylethanolamine acid amidase (NAAA) . Carmofur has anti-cancer, anti-inflammatory and anti-virus activities, and can be used for the study of COVID-19 and acute lung injury (ALI) [1][2][3].
CAS Number
[61422-45-5]
Product Name Alternative
HCFU
UNSPSC
12352005
Hazard Statement
H301, H361
Target
Ceramidase; FAAH; Glutathione Peroxidase; Nucleoside Antimetabolite/Analog; SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/carmofur.html
Purity
99.95
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(N(C(N1)=O)C=C(F)C1=O)NCCCCCC
Molecular Formula
C11H16FN3O3
Molecular Weight
257.26
Precautions
H301, H361
References & Citations
[1]Jin Z, et al. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nat Struct Mol Biol. 2020 Jun;27 (6) :529-532.|[2]Realini N, Solorzano C, Pagliuca C, et al. Discovery of highly potent acid ceramidase inhibitors with in vitro tumor chemosensitizing activity[J]. Scientific reports, 2013, 3 (1) : 1035.|[3]Wu K, et al. A new use for an old drug: carmofur attenuates lipopolysaccharide (LPS) -induced acute lung injury via inhibition of FAAH and NAAA activities[J]. Frontiers in pharmacology, 2019, 10: 818.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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