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Tylvalosin

CAT: 0804-HY-128423A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128423A-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tylvalosin (Acetylisovaleryltylo sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3].
CAS Number
63409-12-1
Product Name Alternative
Acetylisovaleryltylo​sin
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial; NF-κB
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; NF-κB
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tylvalosin.html
Purity
99.00
Solubility
DMSO : 100 mg/mL
Smiles
O[C@@H]1[C@@H](C)O[C@@H](OC[C@H]([C@@H](CC)OC(C[C@@H](OC(C)=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@@H]3O[C@@H](C)[C@H](OC(CC(C)C)=O)[C@@](O)(C)C3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@H]4C)=O)/C=C(C)/C=C/C4=O)[C@H](OC)[C@@H]1OC
Molecular Formula
C53H87NO19
Molecular Weight
1042.25
References & Citations
[1]Albert Philip Adrian Mockett, et al. Use of tylvalosin as antiviral agent. Patent. WO2008007104.|[2]Zhao Z, et al. Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Biochem Pharmacol. 2014 Jul 1;90 (1) :73-87.|[3]Moges R, et al. Anti-Inflammatory Benefits of Antibiotics: Tylvalosin Induces Apoptosis of Porcine Neutrophils and Macrophages, Promotes Efferocytosis, and Inhibits Pro-Inflammatory CXCL-8, IL1α, and LTB4 Production, While Inducing the Release of Pro-Resolving Lipoxin A4 and Resolvin D1. Front Vet Sci. 2018 Apr 11;5:57.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Macrolide

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